FoxM1 dances with mitosis
RH Costa - Nature cell biology, 2005 - nature.com
RH Costa
Nature cell biology, 2005•nature.comThe mammalian Forkhead Box M1 (FoxM1) protein, known for its function as a
transcriptional regulator of G1/S progression, is also crucial for the G2/M transition. Some of
its target genes are cyclin B, Cdc25B phosphatase, Aurora B kinase and Polo-like kinase.
Furthermore, identification of the nuclear protein CENP-F as a transcriptional target of
FoxM1 reveals how it can also regulate the spindle assembly checkpoint, thereby ensuring
proper chromosome stability and segregation during mitosis.
transcriptional regulator of G1/S progression, is also crucial for the G2/M transition. Some of
its target genes are cyclin B, Cdc25B phosphatase, Aurora B kinase and Polo-like kinase.
Furthermore, identification of the nuclear protein CENP-F as a transcriptional target of
FoxM1 reveals how it can also regulate the spindle assembly checkpoint, thereby ensuring
proper chromosome stability and segregation during mitosis.
The mammalian Forkhead Box M1 (FoxM1) protein, known for its function as a transcriptional regulator of G1/S progression, is also crucial for the G2/M transition. Some of its target genes are cyclin B, Cdc25B phosphatase, Aurora B kinase and Polo-like kinase. Furthermore, identification of the nuclear protein CENP-F as a transcriptional target of FoxM1 reveals how it can also regulate the spindle assembly checkpoint, thereby ensuring proper chromosome stability and segregation during mitosis.
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