Publisher Summary Proteolysis is the primary mechanism used by all cells not only to
dispose of unwanted proteins but also to regulate protein function and maintain cellular
homeostasis. Proteases that reside in the endocytic pathway are the principal actors of
terminal protein degradation. The proteases contained in the endocytic pathway are
classified into four major groups based on the active-site amino acid used by the enzyme to
hydrolyze amide bonds of proteins: cysteine, aspartyl, serine, and metalloproteases. The …