Activation of platelets by sera containing igg1 heparin-dependent antibodies: an explanation for the predominance of the Fcγrlla “low responder”(his131) gene in …
GA Denomme, TE Warkentin, P Horsewood… - Journal of Laboratory …, 1997 - Elsevier
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by heparin-
dependent IgG (HIT-IgG) that recognizes a complex of heparin and platelet factor 4 (PF4),
leading to platelet activation via the platelet Fcγlla receptors (FcγRIIa). Not all patients who
generate HIT-IgG in response to heparin develop HIT, however, possibly because of
observed differences in the ability of platelets from healthy individuals to be activated by HIT
sera. It is known that a polymorphism in the platelet FcγRIIa plays an important role in …
dependent IgG (HIT-IgG) that recognizes a complex of heparin and platelet factor 4 (PF4),
leading to platelet activation via the platelet Fcγlla receptors (FcγRIIa). Not all patients who
generate HIT-IgG in response to heparin develop HIT, however, possibly because of
observed differences in the ability of platelets from healthy individuals to be activated by HIT
sera. It is known that a polymorphism in the platelet FcγRIIa plays an important role in …
