A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma
M Tsuneoka, K Teye, N Arima, M Soejima… - Journal of Biological …, 2005 - ASBMB
Myc is a ubiquitous mediator of cell proliferation that transactivates the expression of various
genes through E-box sites. Here we report a novel gene, mimitin (Myc-induced
mitochondrial protein), that encodes a mitochondrial protein with a molecular mass of 20
kDa. We demonstrated that the transcription of mimitin is directly stimulated by c-Myc. To
investigate the role of Mimitin, its expression was suppressed by the RNA interference
(RNAi) technique. Whereas specific inhibition of mimitin expression did not affect cell …
genes through E-box sites. Here we report a novel gene, mimitin (Myc-induced
mitochondrial protein), that encodes a mitochondrial protein with a molecular mass of 20
kDa. We demonstrated that the transcription of mimitin is directly stimulated by c-Myc. To
investigate the role of Mimitin, its expression was suppressed by the RNA interference
(RNAi) technique. Whereas specific inhibition of mimitin expression did not affect cell …
