[HTML][HTML] Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse …
A Zahabi, S Picard, N Fortin, TL Reudelhuber… - Journal of biological …, 2003 - ASBMB
Evidence from several rodent models has suggested that a reduction of either atrial
natriuretic peptide or its receptor in the heart affects cardiac remodeling by promoting the
onset of cardiac hypertrophy. The atrial natriuretic peptide receptor mediates signaling at
least in part via the generation of intracellular cyclic GMP. To directly test whether
accumulation of intracellular cyclic GMP conveys protection against cardiac hypertrophy, we
engineered transgenic mice that overexpress a catalytic fragment of constitutively active …
natriuretic peptide or its receptor in the heart affects cardiac remodeling by promoting the
onset of cardiac hypertrophy. The atrial natriuretic peptide receptor mediates signaling at
least in part via the generation of intracellular cyclic GMP. To directly test whether
accumulation of intracellular cyclic GMP conveys protection against cardiac hypertrophy, we
engineered transgenic mice that overexpress a catalytic fragment of constitutively active …
