Evidence of a link between erythrocyte band 3 phosphorylation and anion transport in patients with'idiopathic'calcium oxalate nephrolithiasis.
B Baggio, L Bordin, G Gambaro, A Piccoli… - Mineral and …, 1993 - europepmc.org
B Baggio, L Bordin, G Gambaro, A Piccoli, G Marzaro, G Clari
Mineral and electrolyte metabolism, 1993•europepmc.orgThis study was carried out to verify the hypothesis of a link between faster endogenous
phosphorylation of band 3 protein, the anion carrier, and anomalous oxalate
transmembrane self-exchange found in erythrocyte from calcium oxalate renal stone
formers. Agents able to modify 32P-labelling of band 3 protein induced a concurrent
modification in oxalate transmembrane flux. Cyclic AMP-and phospholipid-sensitive Ca (2+)-
independent protein kinases seem to be critical modulators of band 3 function. These …
phosphorylation of band 3 protein, the anion carrier, and anomalous oxalate
transmembrane self-exchange found in erythrocyte from calcium oxalate renal stone
formers. Agents able to modify 32P-labelling of band 3 protein induced a concurrent
modification in oxalate transmembrane flux. Cyclic AMP-and phospholipid-sensitive Ca (2+)-
independent protein kinases seem to be critical modulators of band 3 function. These …
This study was carried out to verify the hypothesis of a link between faster endogenous phosphorylation of band 3 protein, the anion carrier, and anomalous oxalate transmembrane self-exchange found in erythrocyte from calcium oxalate renal stone formers. Agents able to modify 32P-labelling of band 3 protein induced a concurrent modification in oxalate transmembrane flux. Cyclic AMP-and phospholipid-sensitive Ca (2+)-independent protein kinases seem to be critical modulators of band 3 function. These observations demonstrate a close link between the band 3 phosphorylation state and its anion transport function, and provide new insights into the pathogenetic mechanisms of the cellular anomalies observed in calcium-oxalate renal stone disease.
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