Responsiveness of hypercalciuria to thiazide in Dent's disease
KA Raja, S Schurman, RG D'Mello… - Journal of the …, 2002 - journals.lww.com
Hypercalciuria is the major risk factor promoting stone formation in Dent's disease, also
known as X-linked recessive nephrolithiasis, but the effects of diuretics on calcium excretion
and other stone risk factors in this disease are unknown. This study examined urine
composition in eight male patients with Dent's disease, ages 6 to 49 yr, all of whom were
hypercalciuric and had inactivating mutations of CLCN5. Eight males, ages 7 to 34 yr, with
idiopathic hypercalciuria (IH) served as controls. Patients were instructed to maintain a …
known as X-linked recessive nephrolithiasis, but the effects of diuretics on calcium excretion
and other stone risk factors in this disease are unknown. This study examined urine
composition in eight male patients with Dent's disease, ages 6 to 49 yr, all of whom were
hypercalciuric and had inactivating mutations of CLCN5. Eight males, ages 7 to 34 yr, with
idiopathic hypercalciuria (IH) served as controls. Patients were instructed to maintain a …