[HTML][HTML] Importin β recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin α
MHC Lam, LJ Briggs, W Hu, TJ Martin… - Journal of Biological …, 1999 - ASBMB
Parathyroid hormone-related protein (PTHrP), expressed in a range of tumors, has
endocrine, autocrine/paracrine, and intracrine actions, some of which relate to its ability to
localize in the nucleus. Here we show for the first time that extracellularly added human
PTHrP (amino acids 1–108) can be taken up specifically by receptor-expressing UMR106.
01 osteogenic sarcoma cells and accumulate to quite high levels in the nucleus and
nucleolus within 40 min. Quantitation of recognition by the nuclear localization sequence …
endocrine, autocrine/paracrine, and intracrine actions, some of which relate to its ability to
localize in the nucleus. Here we show for the first time that extracellularly added human
PTHrP (amino acids 1–108) can be taken up specifically by receptor-expressing UMR106.
01 osteogenic sarcoma cells and accumulate to quite high levels in the nucleus and
nucleolus within 40 min. Quantitation of recognition by the nuclear localization sequence …
