Endothelial cell inflammatory responses to tumor necrosis factor α: ceramide-dependent and-independent mitogen-activated protein kinase cascades
V Modur, GA Zimmerman, SM Prescott… - Journal of Biological …, 1996 - ASBMB
Ceramide generation by stimulated sphingomyelinase activity has been implicated in tumor
necrosis factor α (TNF) signaling of apoptosis and differentiation. We examined the role of
ceramide in a major action of TNF: the initiation of inflammatory events. Sphingomyelinase C
at high levels induced inflammatory protein expression in endothelial cells resulting in
leukocyte adhesion, but the pattern of induction of adhesion molecules (E-selectin, ICAM-1,
VCAM-1) and cytokines (interleukins 6 and 8) differed from that induced by TNF. TNF …
necrosis factor α (TNF) signaling of apoptosis and differentiation. We examined the role of
ceramide in a major action of TNF: the initiation of inflammatory events. Sphingomyelinase C
at high levels induced inflammatory protein expression in endothelial cells resulting in
leukocyte adhesion, but the pattern of induction of adhesion molecules (E-selectin, ICAM-1,
VCAM-1) and cytokines (interleukins 6 and 8) differed from that induced by TNF. TNF …
