Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study
A Ascherio, KL Munger, ET Lennette, D Spiegelman… - Jama, 2001 - jamanetwork.com
ContextEpidemiological studies suggest an association between infection with Epstein-Barr
virus (EBV) and risk of multiple sclerosis (MS). ObjectiveTo determine whether elevation in
serum antibody titers to EBV viral capsid antigen (VCA), nuclear antigens (EBNA, EBNA-1,
and EBNA-2), and diffuse and restricted early antigen (EA-D and EA-R) as well as to
cytomegalovirus (CMV) precede the occurrence of MS. Design, Setting, and
SubjectsProspective, nested case-control study. Of 62 439 women participating in the …
virus (EBV) and risk of multiple sclerosis (MS). ObjectiveTo determine whether elevation in
serum antibody titers to EBV viral capsid antigen (VCA), nuclear antigens (EBNA, EBNA-1,
and EBNA-2), and diffuse and restricted early antigen (EA-D and EA-R) as well as to
cytomegalovirus (CMV) precede the occurrence of MS. Design, Setting, and
SubjectsProspective, nested case-control study. Of 62 439 women participating in the …