Apolipoprotein CIII (apoCIII) plays an important role in plasma triglyceride and remnant
lipoprotein metabolism. Because hypertriglyceridemia is an independent risk factor in
coronary artery disease and the presence in plasma of triglyceride-rich remnant lipoproteins
is correlated with atherosclerosis, considerable research efforts have been focused on the
identification of factors regulating apoCIII gene expression to decrease its production. Here
we report that the orphan nuclear hormone receptor Rev-erbα regulates the human apoCIII …