Pioglitazone, like other thiazolidinediones, is an insulin-sensitizing agent that activates the
peroxisome proliferator-activated receptor γ and influences the expression of multiple genes
involved in carbohydrate and lipid metabolism. However, it is unknown which of these many
target genes play primary roles in determining the antidiabetic and hypolipidemic effects of
thiazolidinediones. To specifically investigate the role of the Cd36 fatty acid transporter gene
in the insulin-sensitizing actions of thiazolidinediones, we studied the metabolic effects of …