[HTML][HTML] MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element
OL Sierra, SL Cheng, AP Loewy… - Journal of Biological …, 2004 - ASBMB
Msx2 promotes osteogenic lineage allocation from mesenchymal progenitors but inhibits
terminal differentiation demarcated by osteocalcin (OC) gene expression. Msx2 inhibits OC
expression by targeting the fibroblast growth factor responsive element (OCFRE), a 42-bp
DNA domain in the OC gene bound by the Msx2 interacting nuclear target protein (MINT)
and Runx2/Cbfa1. To better understand Msx2 regulation of the OCFRE, we have studied
functional interactions between MINT and Runx2, a master regulator of osteoblast …
terminal differentiation demarcated by osteocalcin (OC) gene expression. Msx2 inhibits OC
expression by targeting the fibroblast growth factor responsive element (OCFRE), a 42-bp
DNA domain in the OC gene bound by the Msx2 interacting nuclear target protein (MINT)
and Runx2/Cbfa1. To better understand Msx2 regulation of the OCFRE, we have studied
functional interactions between MINT and Runx2, a master regulator of osteoblast …