[HTML][HTML] Progress on new vaccine strategies against chronic viral infections
JA Berzofsky, JD Ahlers, J Janik… - The Journal of …, 2004 - Am Soc Clin Investig
The Journal of clinical investigation, 2004•Am Soc Clin Investig
Among the most cost-effective strategies for preventing viral infections, vaccines have
proven effective primarily against viruses causing acute, self-limited infections. For these it
has been sufficient for the vaccine to mimic the natural virus. However, viruses causing
chronic infection do not elicit an immune response sufficient to clear the infection and, as a
result, vaccines for these viruses must elicit more effective responses—quantitative and
qualitative—than does the natural virus. Here we examine the immunologic and virologic …
proven effective primarily against viruses causing acute, self-limited infections. For these it
has been sufficient for the vaccine to mimic the natural virus. However, viruses causing
chronic infection do not elicit an immune response sufficient to clear the infection and, as a
result, vaccines for these viruses must elicit more effective responses—quantitative and
qualitative—than does the natural virus. Here we examine the immunologic and virologic …
Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for the vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses — quantitative and qualitative — than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.
The Journal of Clinical Investigation