[HTML][HTML] Soluble collagen VI drives serum-starved fibroblasts through S phase and prevents apoptosis via down-regulation of Bax
M Ruhl, E Sahin, M Johannsen… - Journal of Biological …, 1999 - ASBMB
We previously showed that soluble, pepsin-solubilized collagen VI increases de novo DNA
synthesis in serum-starved HT1080 and 3T3 fibroblasts up to 100-fold compared with
soluble collagen I, reaching 80% of the stimulation caused by 10% fetal calf serum. Here we
show that collagen VI also inhibits apoptotic cell death in serum-starved cells as evidenced
by morphological criteria, DNA laddering, complementary apoptosis assays (terminal
deoxynucleotidyl transferase-mediated dUTP nick end labeling, enzyme-linked …
synthesis in serum-starved HT1080 and 3T3 fibroblasts up to 100-fold compared with
soluble collagen I, reaching 80% of the stimulation caused by 10% fetal calf serum. Here we
show that collagen VI also inhibits apoptotic cell death in serum-starved cells as evidenced
by morphological criteria, DNA laddering, complementary apoptosis assays (terminal
deoxynucleotidyl transferase-mediated dUTP nick end labeling, enzyme-linked …
