Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential …
S Cedeno, DF Cifarelli, AM Blasini, M Paris… - Clinical …, 2003 - Elsevier
The integrity of the Ras/Raf/mitogen-activated protein kinase (MAPK) cascade is critical for
maintenance of T cell tolerance, a process that fails in patients with systemic lupus
erythematosus (SLE). In this study we have examined the activity of mitogen-activated
protein kinases ERK-1 and ERK-2 in resting and TCR-activated peripheral blood T
lymphocytes from patients with SLE. We also examined the binding of Ras guanine
nucleotide exchange factor, human Son of Sevenless (hSos), to cytosolic adapter protein …
maintenance of T cell tolerance, a process that fails in patients with systemic lupus
erythematosus (SLE). In this study we have examined the activity of mitogen-activated
protein kinases ERK-1 and ERK-2 in resting and TCR-activated peripheral blood T
lymphocytes from patients with SLE. We also examined the binding of Ras guanine
nucleotide exchange factor, human Son of Sevenless (hSos), to cytosolic adapter protein …
