cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells
K Hanaoka, WB Guggino - Journal of the American Society of …, 2000 - journals.lww.com
Both epithelial cell proliferation and fluid accumulation are responsible for cyst growth in
autosomal dominant polycystic kidney disease (ADPKD). It was previously reported that the
cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in cysts from
ADPKD patients and suggested that cAMP-stimulated Cl-and fluid secretion occurs through
CFTR. The purpose of this study was to investigate the role of cell proliferation in cyst
formation in ADPKD and to explore further the role of fluid secretion in cyst growth. Primary …
autosomal dominant polycystic kidney disease (ADPKD). It was previously reported that the
cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in cysts from
ADPKD patients and suggested that cAMP-stimulated Cl-and fluid secretion occurs through
CFTR. The purpose of this study was to investigate the role of cell proliferation in cyst
formation in ADPKD and to explore further the role of fluid secretion in cyst growth. Primary …