Mechanisms of acantholysis in pemphigus vulgaris: role of IgG valence
JM Mascaró Jr, A España, Z Liu, X Ding… - Clinical immunology and …, 1997 - Elsevier
Pemphigus vulgaris (PV) is a dermatosis mediated by autoantibodies against desmoglein 3
(Dsg3). It was known that intraperitoneal (ip) injections of PV IgG and PV F (ab′) 2, but not
of PV Fab, into neonatal mice reproduced the key features of the disease in these animals. It
was proposed that crosslinking of antigen by bivalent PV autoantibodies may trigger
acantholysis in PV. In the present study, we have used subcutaneous (sc) injections of PV
IgG and its proteolytic fragments into neonatal mice to test equimolar amounts of these …
(Dsg3). It was known that intraperitoneal (ip) injections of PV IgG and PV F (ab′) 2, but not
of PV Fab, into neonatal mice reproduced the key features of the disease in these animals. It
was proposed that crosslinking of antigen by bivalent PV autoantibodies may trigger
acantholysis in PV. In the present study, we have used subcutaneous (sc) injections of PV
IgG and its proteolytic fragments into neonatal mice to test equimolar amounts of these …