The function of the soluble IL-6 receptor in vivo
M Peters, KHM zum Büschenfelde, S Rose-John - Immunology letters, 1996 - Elsevier
Interleukin-6 (IL-6) is considered an important mediator of acute inflammatory responses.
Moreover, IL-6 functions as a differentiation and growth factor of hematopoietic precursor
cells, B-cells, T-cells, keratinocytes, neuronal cells, osteoclasts and endothelial cells. IL-6
exhibits its action via a receptor complex consisting of a specific IL-6 receptor (IL-6R) and a
signal-transducing subunit (gp130). Soluble forms of both receptor components are
generated by shedding and are found in patients with various diseases such as AIDS …
Moreover, IL-6 functions as a differentiation and growth factor of hematopoietic precursor
cells, B-cells, T-cells, keratinocytes, neuronal cells, osteoclasts and endothelial cells. IL-6
exhibits its action via a receptor complex consisting of a specific IL-6 receptor (IL-6R) and a
signal-transducing subunit (gp130). Soluble forms of both receptor components are
generated by shedding and are found in patients with various diseases such as AIDS …
