p18 (INK4c) belongs to the family of cyclin-dependent kinase inhibitory proteins that target
the cyclin-dependent kinases and inhibit their catalytic activity. The role of p18 (INK4c) for
cell cycle progression in vivo is characterized poorly. Therefore, we studied the expression
and physiologic relevance of p18 in quiescent and proliferating hepatocytes during liver
regeneration. For our analysis we used single-(p18 [INK4c], p27 [KIP1], p21 [CIP1/WAF1]),
and double-mutant (p18/p21, p18/p27) mice. p18 expression was found in quiescent …