Background/Aims: Kupffer cells are involved in local immunoregulation in the liver by
secretion of cytokines and direct cellular contact. They are able to influence the function of
other liver cells, ie sinusoidal endothelial cells, Ito cells and hepatocytes. The three known
major functions of Kupffer cells are clearance of endotoxin from the portal circulation,
release of soluble mediators and presentation of antigen. Methods: Human Kupffer cells
were isolated by collagenase perfusion followed by centrifugal elutriation and analyzed for …