p53 gene mutation and expression in naevi and melanomas
LE Sparrow, R Soong, HJS Dawkins… - Melanoma …, 1995 - journals.lww.com
Mutations of the p53 tumour suppressor gene are common to many human malignancies.
Although increased p53 expression has been observed in cutaneous malignant melanoma,
mutations of the p53 gene appear to be infrequent. We ex-amined 140 benign and
malignant paraffin-embedded melanocytic lesions for p53 protein expression by
immunohistochemistry, using the monoclonal anti-p53 antibody DO-7 and a microwave
method of antigen retrieval. Fifteen naevi and 25 melanomas were further analysed for p53 …
Although increased p53 expression has been observed in cutaneous malignant melanoma,
mutations of the p53 gene appear to be infrequent. We ex-amined 140 benign and
malignant paraffin-embedded melanocytic lesions for p53 protein expression by
immunohistochemistry, using the monoclonal anti-p53 antibody DO-7 and a microwave
method of antigen retrieval. Fifteen naevi and 25 melanomas were further analysed for p53 …
