[HTML][HTML] Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
JR White, JM Lee, PR Young, RP Hertzberg… - Journal of Biological …, 1998 - ASBMB
Interleukin-8 (IL-8) and closely related Glu-Leu-Arg (ELR) containing CXC chemokines,
including growth-related oncogene (GRO) α, GROβ, GROγ, and epithelial cell-derived
neutrophil-activating peptide-78 (ENA-78), are potent neutrophil chemotactic and activating
peptides, which are proposed to be major mediators of inflammation. IL-8 activates
neutrophils by binding to two distinct seven-transmembrane (7-TMR) G-protein coupled
receptors CXCR1 (IL-8RA) and CXCR2 (IL-8RB), while GROα, GROβ, GROγ, and ENA-78 …
including growth-related oncogene (GRO) α, GROβ, GROγ, and epithelial cell-derived
neutrophil-activating peptide-78 (ENA-78), are potent neutrophil chemotactic and activating
peptides, which are proposed to be major mediators of inflammation. IL-8 activates
neutrophils by binding to two distinct seven-transmembrane (7-TMR) G-protein coupled
receptors CXCR1 (IL-8RA) and CXCR2 (IL-8RB), while GROα, GROβ, GROγ, and ENA-78 …