Tumor necrosis factor-α blockade: a novel therapy for rheumatic disease
JC Shanahan, EWS Clair - Clinical Immunology, 2002 - Elsevier
Overproduction of tumor necrosis factor-α (TNF) plays a key role in the pathogenesis of
rheumatoid arthritis (RA) and other chronic inflammatory diseases. In RA, excessive
production of TNF-α can drive synovial inflammation and proliferation as well as degradation
of articular cartilage and bone. The importance of TNF-α in these mechanisms is supported
by the results of clinical trials. In these studies, treatment with etanercept and infliximab, two
recently approved TNF-α inhibitors, has been shown to significantly decrease the signs and …
rheumatoid arthritis (RA) and other chronic inflammatory diseases. In RA, excessive
production of TNF-α can drive synovial inflammation and proliferation as well as degradation
of articular cartilage and bone. The importance of TNF-α in these mechanisms is supported
by the results of clinical trials. In these studies, treatment with etanercept and infliximab, two
recently approved TNF-α inhibitors, has been shown to significantly decrease the signs and …