VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells
EA Beierle, LF Strande, MK Chen - Journal of pediatric surgery, 2002 - Elsevier
Background/Purpose: Both the expression of Bcl-2 and the amount of vascular endothelial
growth factor (VEGF) are increased in neuroblastoma cells cocultured with hepatocytes. The
authors hypothesize that VEGF upregulates Bcl-2 expression by the neuroblastoma cells
and protects them from apoptotic stimuli. Methods: To determine whether VEGF will induce
Bcl-2 expression in neuroblastoma cells, the cells are plated with standard media (control)
or media supplemented with VEGF. After 24 hours, Bcl-2 expression is measured. To …
growth factor (VEGF) are increased in neuroblastoma cells cocultured with hepatocytes. The
authors hypothesize that VEGF upregulates Bcl-2 expression by the neuroblastoma cells
and protects them from apoptotic stimuli. Methods: To determine whether VEGF will induce
Bcl-2 expression in neuroblastoma cells, the cells are plated with standard media (control)
or media supplemented with VEGF. After 24 hours, Bcl-2 expression is measured. To …