Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse
H Yoshiji, S Kuriyama, J Yoshii, Y Ikenaka, R Noguchi… - Hepatology, 2002 - Elsevier
It has been suggested that the tissue inhibitor of metalloproteinases-1 (TIMP-1) is involved in
spontaneous resolution of liver fibrosis. The aim of this study was to investigate whether
TIMP-1 altered spontaneous resolution of liver fibrosis in conjunction with matrix
metalloproteinases (MMP) inhibition and hepatic stellate cell (HSC) activation. The livers of
liver-targeted TIMP-1 transgenic (TIMP-Tg) and control hybrid (Cont) mice were harvested at
0, 3, 7, and 28 days following spontaneous recovery from CCl4-induced liver fibrosis. The …
spontaneous resolution of liver fibrosis. The aim of this study was to investigate whether
TIMP-1 altered spontaneous resolution of liver fibrosis in conjunction with matrix
metalloproteinases (MMP) inhibition and hepatic stellate cell (HSC) activation. The livers of
liver-targeted TIMP-1 transgenic (TIMP-Tg) and control hybrid (Cont) mice were harvested at
0, 3, 7, and 28 days following spontaneous recovery from CCl4-induced liver fibrosis. The …