[HTML][HTML] Regulation of α1 (I) collagen messenger RNA decay by interactions with αCP at the 3′-untranslated region
JN Lindquist, CJ Parsons, B Stefanovic… - Journal of Biological …, 2004 - ASBMB
Liver fibrosis is characterized by an increased deposition of extracellular matrix proteins,
including collagen type I, by activated hepatic stellate cells (HSCs). Previous studies have
shown that this increase is mediated primarily by a post-transcriptional mechanism. In
particular, the RNA-binding protein αCP binds to the α1 (I) collagen 3′-untranslated region
(UTR) and stabilizes this RNA in activated, but not quiescent, HSCs. This study examines
the role of αCP in the decay of transcripts containing the collagen 3′-UTR in extracts …
including collagen type I, by activated hepatic stellate cells (HSCs). Previous studies have
shown that this increase is mediated primarily by a post-transcriptional mechanism. In
particular, the RNA-binding protein αCP binds to the α1 (I) collagen 3′-untranslated region
(UTR) and stabilizes this RNA in activated, but not quiescent, HSCs. This study examines
the role of αCP in the decay of transcripts containing the collagen 3′-UTR in extracts …