Caveolae and caveolin in immune cells: distribution and functions
Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the
presence of the protein caveolin and involved in several cellular processes, including
clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and
signal transduction. Recently, caveolae have been identified as providing a novel route by
which several pathogens are internalized by antigen-presenting cells and as centers for
signal transduction. Here, we review the distribution and role of caveolae and caveolin in …
presence of the protein caveolin and involved in several cellular processes, including
clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and
signal transduction. Recently, caveolae have been identified as providing a novel route by
which several pathogens are internalized by antigen-presenting cells and as centers for
signal transduction. Here, we review the distribution and role of caveolae and caveolin in …
Abstract
Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.
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