Predictors of mefloquine treatment failure: a prospective study of 1590 patients with uncomplicated falciparum malaria
FO Ter Kuile, C Luxemburger, F Nosten… - Transactions of the …, 1995 - Elsevier
The factors which identify patients at risk of treatment failure were characterized in 1590
children and adults with uncomplicated falciparum malaria treated with 15 or 25 mg/kg of
mefloquine on the borders of Thailand. Six independent predictors of failure were identified
using multiple logistic regression. Age⩽ 2 years (odds ratio [OR] 4· 54), 3–15 years (OR 4.4),
vomiting< 30 min after a single dose of 25 mg/kg (despite re-administration of the dose)(OR
2.5) and diarrhoea after treatment (OR 3.6) were the strongest predictors of failure by day 7 …
children and adults with uncomplicated falciparum malaria treated with 15 or 25 mg/kg of
mefloquine on the borders of Thailand. Six independent predictors of failure were identified
using multiple logistic regression. Age⩽ 2 years (odds ratio [OR] 4· 54), 3–15 years (OR 4.4),
vomiting< 30 min after a single dose of 25 mg/kg (despite re-administration of the dose)(OR
2.5) and diarrhoea after treatment (OR 3.6) were the strongest predictors of failure by day 7 …