[HTML][HTML] Inability to induce tolerance through direct antigen presentation
IC Rulifson, GL Szot, E Palmer, JA Bluestone - American Journal of …, 2002 - Elsevier
Both the direct and indirect antigen presentation pathways are important mechanisms for T
cell‐mediated allograft rejection. Studies using knockout mice and monoclonal antibodies
have demonstrated that CD4+ T cells are both necessary and sufficient for the rejection of
allogeneic tissues, including skin, heart, and islet. Furthermore, combined blockade of the
CD28/B7 and CD154/CD40 costimulatory pathways induces tolerance in multiple CD4+ T‐
cell dependent allograft models. In this study, we addressed the T‐cell requirement for …
cell‐mediated allograft rejection. Studies using knockout mice and monoclonal antibodies
have demonstrated that CD4+ T cells are both necessary and sufficient for the rejection of
allogeneic tissues, including skin, heart, and islet. Furthermore, combined blockade of the
CD28/B7 and CD154/CD40 costimulatory pathways induces tolerance in multiple CD4+ T‐
cell dependent allograft models. In this study, we addressed the T‐cell requirement for …
