Expression of the Rat Liver Na+/Taurocholate Cotransporter Is RegulatedIn VivoBy Retention of Biliary Constituents But Not Their Depletion
C Gartung, S Schuele, SF Schlosser, JL Boyer - Hepatology, 1997 - journals.lww.com
Expression and function of the hepatic Na+/taurocholate cotransporter (ntcp) are down–
regulated in several models of experimental cholestasis. To test whether retention and/or
depletion of biliary constituents are involved inntcpregulation, ntcpexpression was quantified
in several animal models with altered levels of these constituents. In choledochocaval fistula
rats (CCF)(retention model), ntcpmRNA expression specifically declined after 1 and 3 days
by 76±4%(P<. 005) and 31±9%(P<. 05), respectively, returning to control levels by 7 days …
regulated in several models of experimental cholestasis. To test whether retention and/or
depletion of biliary constituents are involved inntcpregulation, ntcpexpression was quantified
in several animal models with altered levels of these constituents. In choledochocaval fistula
rats (CCF)(retention model), ntcpmRNA expression specifically declined after 1 and 3 days
by 76±4%(P<. 005) and 31±9%(P<. 05), respectively, returning to control levels by 7 days …
