Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain (∗)
S Soker, H Fidder, G Neufeld, M Klagsbrun - Journal of Biological …, 1996 - ASBMB
Vascular endothelial growth factor (VEGF), a potent angiogenic factor, uses two receptor
tyrosine kinases, FLK/KDR and FLT, to mediate its activities. We have cross-linked 125 I-
VEGF 165 to the cell surface of various tumor cell lines and of human umbilical vein
endothelial cells. High molecular mass (220 and 240 kDa) and/or lower molecular mass
(165 and 175 kDa) labeled complexes were detected depending on the cell type. The 220-
and 240-kDa labeled complexes were shown to contain FLT and FLK/KDR receptors …
tyrosine kinases, FLK/KDR and FLT, to mediate its activities. We have cross-linked 125 I-
VEGF 165 to the cell surface of various tumor cell lines and of human umbilical vein
endothelial cells. High molecular mass (220 and 240 kDa) and/or lower molecular mass
(165 and 175 kDa) labeled complexes were detected depending on the cell type. The 220-
and 240-kDa labeled complexes were shown to contain FLT and FLK/KDR receptors …
