Synthesis, transport, and release of posterior pituitary hormones

MJ Brownstein, JT Russell, H Gainer - Science, 1980 - science.org
MJ Brownstein, JT Russell, H Gainer
Science, 1980science.org
Vasopressin and oxytocin are made and released by neurons of the hypothalamo-
neurohypophysial system. Pulse labeling these neurons with radioactive amino acid
indicates that the two hormones and their respective neurophysin carrier proteins are
synthesized as parts of separate precursor proteins. The precursors seem to be processed
into smaller, biologically active molecules while they are being transported along the axon.
Vasopressin and oxytocin are made and released by neurons of the hypothalamo-neurohypophysial system. Pulse labeling these neurons with radioactive amino acid indicates that the two hormones and their respective neurophysin carrier proteins are synthesized as parts of separate precursor proteins. The precursors seem to be processed into smaller, biologically active molecules while they are being transported along the axon.
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