CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms
AC Grammer, PE Lipsky - Advances in immunology, 2001 - Elsevier
CD40 and CD154/CD40 ligand (Fig. 1) are members of the tumor necrosis factor (TNF)
superfamily and are known to play a crucial role in normal T cell–dependent and T cell–
independent humoral immune responses to both bacteria and viruses. In addition,
interactions between these molecules in normal individuals are essential for a panoply of
immune responses, including the induction of oral tolerance, the activation of antigen-
presenting cells, and the function of tumoricidal natural killer cells, macrophages, and …
superfamily and are known to play a crucial role in normal T cell–dependent and T cell–
independent humoral immune responses to both bacteria and viruses. In addition,
interactions between these molecules in normal individuals are essential for a panoply of
immune responses, including the induction of oral tolerance, the activation of antigen-
presenting cells, and the function of tumoricidal natural killer cells, macrophages, and …
