Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
P Rieckmann, M Albrecht, B Kitze, T Weber, H Tumani… - Neurology, 1994 - AAN Enterprises
P Rieckmann, M Albrecht, B Kitze, T Weber, H Tumani, A Broocks, W Luer, S Poser
Neurology, 1994•AAN EnterprisesWe determined the cytokine messenger RNA (mRNA) expression pattern of blood
mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with
other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we
detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in
patients with relapsing compared to those with stable disease (p< 0.001), but transforming
growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable …
mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with
other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we
detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in
patients with relapsing compared to those with stable disease (p< 0.001), but transforming
growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable …
We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in patients with relapsing compared to those with stable disease (p < 0.001), but transforming growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable disease.
American Academy of Neurology