Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
Interleukin-12 (IL-12) is a proinflammatory cytokine produced by antigen-presenting cells in
response to many microbial infections. IL-12 plays an important role in the generation of T
helper type-1 cells, which favor cell-mediated immune response. IL-12 is composed of two
different subunits, p40 and p35, whose expression can be regulated concomitantly or
differentially. Monocytic cells, the major producers of IL-12, can be primed by interferon-γ
(IFN-γ) to produce optimal amounts of IL-12 in response to LPS stimulation as a …
response to many microbial infections. IL-12 plays an important role in the generation of T
helper type-1 cells, which favor cell-mediated immune response. IL-12 is composed of two
different subunits, p40 and p35, whose expression can be regulated concomitantly or
differentially. Monocytic cells, the major producers of IL-12, can be primed by interferon-γ
(IFN-γ) to produce optimal amounts of IL-12 in response to LPS stimulation as a …
