Capillary thrombosis as a cause of death in experimental anthrax

FG Dalldorf, FA Beall - Arch. Pathol, 1967 - apps.dtic.mil
FG Dalldorf, FA Beall
Arch. Pathol, 1967apps.dtic.mil
The lungs of rats, rabbits, and guinea pigs that died of anthrax septicemia were studied by
light and electron microscopy. In all three species, the clinical signs of respiratory failure that
occurred during the terminal phase of the disease were associated with widespread
pulmonary capillary thrombosis. The thrombi occurred in intact capillaries and were
composed of platelets and fibrin. These results are compared with previous observations in
rats given anthrax toxin and the significance of pulmonary capillary thrombosis as a factor in …
Abstract
The lungs of rats, rabbits, and guinea pigs that died of anthrax septicemia were studied by light and electron microscopy. In all three species, the clinical signs of respiratory failure that occurred during the terminal phase of the disease were associated with widespread pulmonary capillary thrombosis. The thrombi occurred in intact capillaries and were composed of platelets and fibrin. These results are compared with previous observations in rats given anthrax toxin and the significance of pulmonary capillary thrombosis as a factor in the cause of death in anthrax is discussed.
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