[HTML][HTML] Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A

M Fukuda - Journal of Biological Chemistry, 2002 - ASBMB
The N-terminal synaptotagmin-like protein (Slp) homology domain (SHD) of the Slp and
Slac2 families has recently been identified as a specific Rab27A-binding domain (Kuroda,
TS, Fukuda, M., Ariga, H., and Mikoshiba, K.(2002) J. Biol. Chem. 277, 9212–9218; Fukuda,
M., Kuroda, TS, and Mikoshiba, K.(2002) J. Biol. Chem. 277, 12432–12436). The SHD
consists of two conserved α-helical regions (SHD1 and SHD2) that are often separated by
two zinc finger motifs. However, the structural basis of Rab27A recognition by the SHD (ie …