[HTML][HTML] A family of Rab27-binding proteins: melanophilin links Rab27a and myosin Va function in melanosome transport
M Strom, AN Hume, AK Tarafder, E Barkagianni… - Journal of Biological …, 2002 - ASBMB
The Rab27a GTPase regulates diverse processes involving lysosome-related organelles,
including melanosome motility in melanocytes, and lytic granule release in cytotoxic T
lymphocytes. Toward an understanding of Rab27a function, we searched for proteins that
interact with Rab27a (GTP) using the yeast two-hybrid system and identified JFC1/Slp1, a
protein of unknown function. JFC1/Slp1 and related proteins, including melanophilin,
contain a conserved amino-terminal domain similar to the Rab3a-binding domain of …
including melanosome motility in melanocytes, and lytic granule release in cytotoxic T
lymphocytes. Toward an understanding of Rab27a function, we searched for proteins that
interact with Rab27a (GTP) using the yeast two-hybrid system and identified JFC1/Slp1, a
protein of unknown function. JFC1/Slp1 and related proteins, including melanophilin,
contain a conserved amino-terminal domain similar to the Rab3a-binding domain of …
