Short-term inhibition of carnitine palmitoyltransferase I activity in rat hepatocytes incubated with ethanol
M Guzmán, MJH Geelen - Biochemical and biophysical research …, 1988 - Elsevier
M Guzmán, MJH Geelen
Biochemical and biophysical research communications, 1988•ElsevierEthanol decreased the activity of carnitine palmitoyltransferase I and the rate of fatty acid
oxidation in rat hepatocytes in short-term incubations. These effects were mimicked by
acetaldehyde, the product of hepatic ethanol metabolism, and were absent when ethanol
oxidation was prevented by 4-methylpyrazole. Ethanol was also able to increase
intracellular malonyl-CoA levels. The results suggest that inhibition of fatty acid translocation
into mitochondria may play an important role in the ethanol-induced inhibition of hepatic fatty …
oxidation in rat hepatocytes in short-term incubations. These effects were mimicked by
acetaldehyde, the product of hepatic ethanol metabolism, and were absent when ethanol
oxidation was prevented by 4-methylpyrazole. Ethanol was also able to increase
intracellular malonyl-CoA levels. The results suggest that inhibition of fatty acid translocation
into mitochondria may play an important role in the ethanol-induced inhibition of hepatic fatty …
Abstract
Ethanol decreased the activity of carnitine palmitoyltransferase I and the rate of fatty acid oxidation in rat hepatocytes in short-term incubations. These effects were mimicked by acetaldehyde, the product of hepatic ethanol metabolism, and were absent when ethanol oxidation was prevented by 4-methylpyrazole. Ethanol was also able to increase intracellular malonyl-CoA levels. The results suggest that inhibition of fatty acid translocation into mitochondria may play an important role in the ethanol-induced inhibition of hepatic fatty acid oxidation.
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