H ypoxia contributes significantly to the pathophysiology of major categories of human
disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension,
congenital heart disease, and chronic obstructive puhnonary disease. A greater
understanding of the molecular mechanisms underlying physiologic and pathophysiologic
responses to hypoxia may therefore present novel approaches for treating the most common
causes of morbidity and mortality in the United States. All mammalian cells can sense …