[HTML][HTML] Cystic fibrosis transmembrane conductance regulator: structure and function of an epithelial chloride channel
MH Akabas - Journal of Biological Chemistry, 2000 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) 1 forms a Cl channel that
is an essential component of epithelial Cl transport systems in many organs, including the
intestines, pancreas, lungs, sweat glands, and kidneys. In the Cl secretory intestinal
epithelium, Cl enters the cells through a Na-K-2Cl cotransporter in the basolateral
membrane and exits through CFTR in the apical membrane; water follows osmotically (1).
Absorptive epithelia use similar transporters and channels, but their polarized distribution …
is an essential component of epithelial Cl transport systems in many organs, including the
intestines, pancreas, lungs, sweat glands, and kidneys. In the Cl secretory intestinal
epithelium, Cl enters the cells through a Na-K-2Cl cotransporter in the basolateral
membrane and exits through CFTR in the apical membrane; water follows osmotically (1).
Absorptive epithelia use similar transporters and channels, but their polarized distribution …
