Sensorimotor gating in boys with Tourette's syndrome and ADHD: preliminary results
FX Castellanos, EJ Fine, D Kaysen, WL Marsh… - Biological …, 1996 - Elsevier
Deficits in sensorimotor gating, defined by prepulse inhibition (PPI), have been associated
with subcortical dopaminergic overactivity in animal and clinical studies. Utilizing
supraorbital nerve electrical stimulation, we produced adequate blink responses and
measured decreases in amplitude resulting from electric prestimuli just above sensory
threshold. Seven boys comorbid for attention-deficit hyperactivity disorder (ADHD) and a tic
disorder had significantly reduced PPI, compared to 14 screened controls and seven boys …
with subcortical dopaminergic overactivity in animal and clinical studies. Utilizing
supraorbital nerve electrical stimulation, we produced adequate blink responses and
measured decreases in amplitude resulting from electric prestimuli just above sensory
threshold. Seven boys comorbid for attention-deficit hyperactivity disorder (ADHD) and a tic
disorder had significantly reduced PPI, compared to 14 screened controls and seven boys …
