Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia

DM Barch, CS Carter, TS Braver… - Archives of general …, 2001 - jamanetwork.com
Background Previously we proposed that dorsolateral prefrontal cortex (PFC) supports a
specific working memory (WM) subcomponent: the ability to represent and maintain context
information necessary to guide appropriate task behavior. By context, we mean prior task-
relevant information represented in such a form that it supports selection of the appropriate
behavioral response. Furthermore, we hypothesized that WM deficits in schizophrenia reflect
impaired context processing due to a disturbance in dorsolateral PFC. We use functional …