Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17

LD Selemon, G Rajkowska… - Archives of general …, 1995 - jamanetwork.com
Background: In the past two decades, gross morphologic changes have been uncovered in
the schizophrenic brain, eg, increased ventricular width and decreased cortical volume;
however, relatively little is known about the area-specific and laminar density of cells in the
schizophrenic cortex, particularly in prefrontal areas. Method: A direct, three-dimensional
counting method was used to determine cell density in 16 brains from patients with
schizophrenia, 19 from normal subjects, six from patients with schizoaffective disorder, and …