Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells
K Takeda, T Hatai, TS Hamazaki, H Nishitoh… - Journal of Biological …, 2000 - ASBMB
Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated
protein kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38
mitogen-activated protein kinase signaling cascades. We report here that expression of
constitutively active ASK1 (ASK1ΔN) induces neurite outgrowth in the rat
pheochromocytoma cell line PC12. We found that p38 and to a lesser extent JNK, but not
ERK, were activated by the expression of ASK1ΔN in PC12 cells. ASK1ΔN-induced neurite …
protein kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38
mitogen-activated protein kinase signaling cascades. We report here that expression of
constitutively active ASK1 (ASK1ΔN) induces neurite outgrowth in the rat
pheochromocytoma cell line PC12. We found that p38 and to a lesser extent JNK, but not
ERK, were activated by the expression of ASK1ΔN in PC12 cells. ASK1ΔN-induced neurite …
