The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes
MR Lieber - Genes to Cells, 1999 - Wiley Online Library
MR Lieber
Genes to Cells, 1999•Wiley Online LibraryRecent progress over the past year has provided new insights into the proteins involved in
nonhomologous end joining. The assembly of Ku and DNA‐dependent protein kinase at
DNA ends is now understood in greater detail. Murine genetic knockouts for DNA ligase IV
and XRCC4 are embryonic lethal, indicating that nonhomologous end joining is essential for
viability. Interestingly, neurones, in addition to lymphocytes, are particularly vulnerable to an
absence of NHEJ.
nonhomologous end joining. The assembly of Ku and DNA‐dependent protein kinase at
DNA ends is now understood in greater detail. Murine genetic knockouts for DNA ligase IV
and XRCC4 are embryonic lethal, indicating that nonhomologous end joining is essential for
viability. Interestingly, neurones, in addition to lymphocytes, are particularly vulnerable to an
absence of NHEJ.
Recent progress over the past year has provided new insights into the proteins involved in nonhomologous end joining. The assembly of Ku and DNA‐dependent protein kinase at DNA ends is now understood in greater detail. Murine genetic knockouts for DNA ligase IV and XRCC4 are embryonic lethal, indicating that nonhomologous end joining is essential for viability. Interestingly, neurones, in addition to lymphocytes, are particularly vulnerable to an absence of NHEJ.
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