Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin
P Dupouey, C Jacque, JM Bourre, F Cesselin… - Neuroscience …, 1979 - Elsevier
P Dupouey, C Jacque, JM Bourre, F Cesselin, A Privat, N Baumann
Neuroscience letters, 1979•ElsevierThe myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its
central nervous system (CNS). Less than 3% of the normal content in MBP is present in a
brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence
is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to
other hypomelinating mutants) stems from the specificity of this genetic lesion, ie the lack of
basic protein.
central nervous system (CNS). Less than 3% of the normal content in MBP is present in a
brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence
is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to
other hypomelinating mutants) stems from the specificity of this genetic lesion, ie the lack of
basic protein.
Abstract
The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS). Less than 3% of the normal content in MBP is present in a brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to other hypomelinating mutants) stems from the specificity of this genetic lesion, i.e. the lack of basic protein.
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