Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7α-hydroxylase gene repression by bile acids
KS Bramlett, S Yao, TP Burris - Molecular Genetics and Metabolism, 2000 - Elsevier
Cholesterol conversion to bile acids in the liver is regulated by the rate-limiting enzyme
cholesterol 7α-hydroxylase (CYP7A1). CYP7A1 activity is regulated by feedback repression
by bile acids at the transcriptional level. The farnesoid X receptor (FXR), a member of the
nuclear hormone receptor superfamily, was recently demonstrated to function as the bile
acid receptor and its high level of expression in the liver implicates it in the transcriptional
regulation of CYP7A1. This study compares the potencies of various bile acids in their ability …
cholesterol 7α-hydroxylase (CYP7A1). CYP7A1 activity is regulated by feedback repression
by bile acids at the transcriptional level. The farnesoid X receptor (FXR), a member of the
nuclear hormone receptor superfamily, was recently demonstrated to function as the bile
acid receptor and its high level of expression in the liver implicates it in the transcriptional
regulation of CYP7A1. This study compares the potencies of various bile acids in their ability …