[HTML][HTML] pH alterations “reset” Ca2+ sensitivity of brain Na+ channel 2, a degenerin/epithelial Na+ ion channel, in planar lipid bilayers
BK Berdiev, TB Mapstone, JM Markert… - Journal of Biological …, 2001 - ASBMB
Members of the degenerin/epithelial Na+ channel superfamily of ion channels subserve
many functions, ranging from whole body sodium handling to mechanoelectrical
transduction. We studied brain Na+ channel 2 (BNaC-2) in planar lipid bilayers to examine
its single channel properties and regulation by Ca 2+. Upon incorporation of vesicles made
from membranes of oocytes expressing either wild-type (WT) BNaC-2 or BNaC-2 with a gain-
of-function (GF) point mutation (G433F), functional channels with different properties were …
many functions, ranging from whole body sodium handling to mechanoelectrical
transduction. We studied brain Na+ channel 2 (BNaC-2) in planar lipid bilayers to examine
its single channel properties and regulation by Ca 2+. Upon incorporation of vesicles made
from membranes of oocytes expressing either wild-type (WT) BNaC-2 or BNaC-2 with a gain-
of-function (GF) point mutation (G433F), functional channels with different properties were …
